Clicking Show button on each mutation record in Step 3 may open a new page with more details. This page contained four important parts:
1. Target information:
In the Target information panel, a window in the left part displays the 3D structure of the protein by using JSMol plugin,Visualization of mutations on 3D structures. The mutated residue is displayed as spheres.
And in the right part, there is a table of general information of the protein and its mutation information, such as Gene Symbol, NCBI Gene ID, Function, Ensembl ID, PDB ID, Driver Mutation, Location, Area,and Driver Gene.
Hover on the Function to get details of gene functions.
2. Known drugs on the target:
The table indicates the known therapeutic modulators targeting this protein in DrugBank and CHEMBL database.